Population Pharmacokinetics and Metabolomics of Theophylline in Preterm Infants

Apea of Prematurity Clinical Trial

Official title: Population Pharmacokinetics and Metabolomic Analysis of Aminopylline/Theophylline Drug Levels in Preterm Infants With Apnea of Prematurity

Status Enrolling by invitation

Clinical Trial Summary

1. Population pharmacokinetics : The purpose of this study is

• to investigate the population pharmacokinetics of theophylline in premature Korean infants and to assess the influence of demographic and clinical covariates.

2. Metabolomics : The purpose of this study are

• to predict serum theophylline levels and to assess CYP1A2 activities in premature infants by analyzing urinary metabolites of theophylline

• to examine which factors affect clearance of theophylline and CYP1A2 activity in premature infants

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Apea of Prematurity
• Premature Birth

• NCT number: NCT01509248
• Study type: Observational
• Source: Seoul National University Hospital
• Status: Enrolling by invitation
• Phase: N/A
• Start date: May 2010