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Myeloid Cells in Aortic Valve Stenosis — MIRACLE  

Aortic Valve Stenosis Clinical Trial

Official title:
Myeloid Cell Reprogramming in Aortic Valve Stenosis

Clinical Trial Summary

Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.

Clinical Trial Description

Calcific aortic valve disease (CAVD) is the most common type of valvular heart disease in the Western world. Due to the aging of the population, the impact of this disorder is expected to further increase in the next decades. The underlying pathophysiology remains incompletely defined and there are currently no effective medical treatments capable of altering its course, identifying a major unmet need in this growing population of patients. Based on the similarities between CAVD and atherosclerosis in pathophysiology and shared risk factors, it is now hypothesized that activation of the innate immune system contributes to the development of CAVD. Therefore, the investigators will perform an observational study to assess the role of activation of the innate immune system in CAVD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04717219
Study type Observational
Source Radboud University Medical Center
Contact Niels P. Riksen, prof. dr.
Phone +31-343618819
Email Niels.Riksen@radboudumc.nl
Status Recruiting
Phase
Start date November 19, 2020
Completion date December 31, 2022
View Details
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