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Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

Aortic Valve Stenosis Clinical Trial

Official title:
Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

Clinical Trial Summary

Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously. However, in doing so, blood flow patterns to the heart muscle change through mechanisms which are incompletely understood. New technology allows such heart valve blockages to be fixed using balloons and metal stents inserted through tubes placed in arteries in the leg. Using sensors placed in these tubes it is possible to make detailed measurements of coronary flow and pressure, and apply new mathematical techniques to allow a better understanding of the detrimental effects that aortic stenosis has on coronary flow, before and after valve surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01118442
Study type Observational
Source Imperial College London
Contact Justin E Davies, MRCP, PhD
Phone 020 7594 33 86
Email justin.davies@imperial.ac.uk
Status Recruiting
Phase N/A
Start date December 2009
Completion date December 2019
View Details
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