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Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis

Aortic Valve Stenosis Clinical Trial

Official title:
Interest of Statin in Surgical Aortic Stenosis: From Myocardial Preconditioning to Ventricular Reverse Remodeling.

Clinical Trial Summary

The purpose of the study is to see if statin therapy will optimize myocardial response to cardiopulmonary bypass during aortic valve replacement (AVR) for aortic valve stenosis (AVS) (Phase I) and optimize left ventricular reverse remodeling following AVR (Phase II). Preliminary evidence indicates that perioperative statin therapy reduce mortality and morbidity following cardiac surgery. Pleiotropic effects of statins may induce myocardial preconditioning and optimize myocardial and systemic responses to cardiopulmonary bypass during AVR. Furthermore statin therapy after AVR may contribute to an optimal left ventricular reverse remodeling.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00811330
Study type Interventional
Source University Hospital, Strasbourg, France
Contact Michel KINDO, MD
Phone 33.3.69.55.08.11
Email michel.kindo@chru-strasbourg.fr
Status Recruiting
Phase Phase 3
Start date December 2008
Completion date January 2018
View Details
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