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Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications — GENERAC  

Aortic Valve Stenosis Clinical Trial

Official title:
Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications

Clinical Trial Summary

Pathophysiology of Aortic Valve Stenosis remains poorly known. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design.

Clinical Trial Description

Aortic valve stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS has long been considered as a passive and degenerative process. Recent data challenged this concept, showing that AS is an active and highly regulated process with some similarities to atherosclerosis. However, pathophysiology of AS remains poorly understood and preliminary data suggest that genetic factors may be involved. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design (1000 patients with AS and 1500 controls with no evidence of valve disease). For all patients and controls, blood samples including DNA and echocardiography will be performed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00647088
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact
Status Recruiting
Phase N/A
Start date March 2008
Completion date December 2017
View Details
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