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Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB — REVERSE-AR  

Aortic Valve Insufficiency Clinical Trial

Official title:
Multicenter, Randomized, Open-label Trial to Assess the Efficacy of Sacubitril/Valsartan vs. Amlodipine/Losartan on Left Ventricular Remodeling in Patients With Chronic Severe Aortic Regurgitation

Clinical Trial Summary

The purpose of this study is to assess the efficacy of sacubitril-valsartan compared to the combination of ARB/CCB on left ventricular remodeling in patients with chronic aortic valve regurgitation.

Clinical Trial Description

After being informed consent about the study and potential risk, all patients giving written informed consent will undergo a 1 month screening period to determine eligibility for study entry. At week 0, patients who meet the eligibility requirements will be randomized in an open-label manner in a 1:1 ratio to sacubitril-valsartan or amlodipine/losartan. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05212597
Study type Interventional
Source Samsung Medical Center
Contact Eun Kyoung Kim, MD. PhD
Phone 82-2-3410-3419
Email ekbobi.kim@samsung.com
Status Recruiting
Phase Phase 2
Start date January 12, 2022
Completion date December 2024
View Details
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