Aortic Dissection Clinical Trial
— RALADOfficial title:
The Relationship Between ALDH2 and Aortic Dissection
NCT number | NCT02630212 |
Other study ID # | 2015QLMS37 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | December 2015 |
Est. completion date | December 2019 |
Verified date | December 2018 |
Source | Qilu Hospital of Shandong University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | December 2019 |
Est. primary completion date | December 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Chinese Han people diagnosed with aortic dissection in Qilu Hospital Exclusion Criteria: - Aortic dissection based on trauma, connective tissue diseases and pregnancy - Patients with tumor - Patients with no written consensus |
Country | Name | City | State |
---|---|---|---|
China | Qilu Hospital of Shandong University | Jinan | Shandong |
Lead Sponsor | Collaborator |
---|---|
Qilu Hospital of Shandong University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of patients with different ALDH2 genotype | DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene. | 1-30 days after samples collected | |
Secondary | Concentration of inflammatory factors in blood and aortic specimen | Concentration of 4-HNE?MMP-2?MMP-9 detected by elisa kit?IHC or western blot in relevant specimen. | 1-30 days after samples collected | |
Secondary | ALDH2 activity | Activity of ALDH2 was detected in blood and aortic specimen depend on its reducibility of NAD+ | 1-30 days after samples collected |
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