Clinical Trials Logo

Clinical Trial Summary

The objective of INSTEAD is to compare long-term (5 years) outcomes of endograft prosthesis versus medical management in patients with dissection of the thoracic aorta.


Clinical Trial Description

Patients > 18 years with type B aortic dissection were randomized to either thoracic aortic endoprosthesis (stent-grafting) or antihypertensive management (medical treatment). Only stable patients without spontaneous false lumen thrombosis 14 days after index dissection were considered eligible for study inclusion. Long-term outcome measures included all-cause mortality, aorta-specific mortality and a cluster endpoint (reflecting progression of disease, conversion and additional interventions); the analysis is based on 140 randomized cases followed for at least 5 years. ;


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01415804
Study type Interventional
Source University of Rostock
Contact
Status Completed
Phase Phase 2/Phase 3
Start date February 2002
Completion date March 2011

See also
  Status Clinical Trial Phase
Completed NCT05582967 - The DAShED (Diagnosis of Aortic Syndrome in the ED) Study
Terminated NCT04116684 - Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients N/A
Completed NCT02086136 - Aortic Dissection Detection Risk Score Plus D-dimer in Suspected Acute Aortic Dissection
Recruiting NCT02201589 - Feasibility of Endovascular Repair Of Ascending Aortic Pathologies N/A
Recruiting NCT03948555 - Magnetic Resonance Imaging (MRI) for Aortic Dissection to Visualise Inflammation
Enrolling by invitation NCT05912608 - Optimal Strategy for Repair of Type A Acute Aortic Dissection
Recruiting NCT03707743 - Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
Enrolling by invitation NCT00583817 - Endovascular Treatment of Thoracic Aortic Disease N/A
Recruiting NCT05073991 - Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
Not yet recruiting NCT02523300 - Glucocorticoid on the Prognosis of TEVAR N/A
Completed NCT01197651 - Aortic-Stent-Register N/A
Recruiting NCT04471909 - NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness N/A
Not yet recruiting NCT06044259 - Study Comparing Hemiarch Replacement and Hemiarch Plus Stent Implantation in Acute Aortic Dissection N/A
Completed NCT05039814 - Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
Recruiting NCT03780738 - A Validation Study of The Relationship Between ALDH2 and Aortic Dissection
Completed NCT03647566 - 18F Sodium Fluoride PET/CT in Acute Aortic Syndrome
Enrolling by invitation NCT05800743 - Evaluation of the GORE® Ascending Stent Graft N/A
Recruiting NCT03347812 - Clinical Study for Evaluating the Safety and Efficacy of Total Endovascular Aortic Arch Repair N/A
Completed NCT05044494 - Surgery for Delay-recognized or Defer-operated Type A Aortic Dissection
Terminated NCT02958098 - My Research Legacy Pilot Study