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Aortic Coarctation clinical trials

View clinical trials related to Aortic Coarctation.

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NCT ID: NCT06150560 Recruiting - High Blood Pressure Clinical Trials

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

VALUE
Start date: April 1, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

NCT ID: NCT05842876 Recruiting - Clinical trials for Coarctation of Aorta

Happy Baby Hearts Study

Start date: April 19, 2023
Phase:
Study type: Observational

The goal of this observational study is to determine the feasibility of renal Near Infrared Spectroscopy (NIRS) monitoring in the newborn nursery for newborns at low risk of coarctation of the aorta (CoA). The main questions it aims to answer are: - whether continuous renal NIRS monitoring is feasible; - whether NIRS monitoring results in higher nursing and parent/caregiver satisfaction than current standard monitoring; and, - whether participants who develop CoA will spend a smaller proportion of time within the normal range than patients who do not have CoA. Participants will be observed through continuous renal oxygenation monitoring with NIRS.

NCT ID: NCT05362721 Recruiting - Clinical trials for Coarctation of Aorta

PV Loop & Coarctation Study

Start date: June 4, 2019
Phase:
Study type: Observational

Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.

NCT ID: NCT05203874 Recruiting - Clinical trials for Congenital Heart Disease

Contribution of Multimodal Imaging in Early Coarctation

CT-COARCT-PED
Start date: January 1, 2022
Phase:
Study type: Observational

The CT-Coarct-PED study is a multicentred observational study aiming to describe the population of early coarctation during the last 10 years in South of France. The secondary objective is to assess the importance of cross-sectional imaging in the surgical management of aortic coarctation in the first year of life

NCT ID: NCT05132946 Recruiting - Anesthesia Clinical Trials

Ultrasound-guided Erector Spinae Plane Block: A Comparative Study to Assess Its Analgesic Efficacy in Pediatric Patients Undergoing Aortic Coarctation Repair

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

The study will include 40 patients who fulfil all the points in the inclusion and exclusion criteria will be randomized into two equal groups, each consisting of 20 patients, namely group (B) and group (C). - Group (B): will receive erector spinae plane block. - Group (C): will not receive any block. Postoperative pain score will be assessed using the FLACC scale or Face, Legs, Activity, Cry, Consolability scale immediately after extubation and at 1, 2, 4, 6, 8, 12, 18, and 24 hours. Routine postoperative analgesia in the form of intravenous paracetamol 7.5 mg/kg/6 hours will be given to all patients (the first dose is given after skin closure). Rescue analgesia in the form of 1 ug/kg fentanyl intravenously for patients if FLACC scale > 4, and the time for the first rescue analgesic administration will be recorded.

NCT ID: NCT04106479 Recruiting - Tetralogy of Fallot Clinical Trials

NIRS in Congenital Heart Defects - Correlation With Echocardiography

Start date: October 11, 2019
Phase:
Study type: Observational

Neonatal patients with congenital heart defects (CHD) have changing physiology in the context of transitional period. Patients with CHD are at risk of low perfusion status or abnormal pulmonary blood flow. Near infrared spectroscopy has been used in neonatal intensive care units (NICU) to measure end-organ perfusion. The investigator plan on monitoring newborns with CHD admitted to the NICU with NIRS and echocardiography during the first week of life and correlate measures of perfusion from Dopplers to cerebral and renal NIRS.

NCT ID: NCT04011956 Recruiting - Clinical trials for Coarctation of Aorta

Prognosis and Integrative Assessment of Aortic Coarctation Patients in China

Start date: March 1, 2019
Phase:
Study type: Observational

This is a systemic research of Chinese aortic coarctation patients, aiming to determine risk factors and serial biomarkers of aortic coarctation in prognosis.

NCT ID: NCT03588312 Recruiting - Clinical trials for Congenital Hypoplasia of Aortic Arch

Long Term Results in Hypoplastic Aortic Arch Repair in Neonates Using a Glutaraldehyde Treated Autologous Pericardial Patch

Aortoplasty
Start date: January 1, 2018
Phase:
Study type: Observational

Hypoplastic aortic arch is a congenital heart defect that is prejudicial for the growth of newborns. It is often associated to other heart defects. Different surgical techniques exist to address this defect, but the literature is very poor with regards to the use of an autologous pericardial patch. Most use extensive dissection techniques or synthetic patches. Here investigators report institution's original approach using the newborns own pericardium for what investigators believe to be an optimal correction of the hypoplasia., with preserved growth potential.

NCT ID: NCT03262753 Recruiting - Arterial Stiffness Clinical Trials

Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment

LOVE-COARCT
Start date: June 1, 2013
Phase: N/A
Study type: Observational

Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities. Methods: Vascular function in large and small arteries will be prospectively assessed fusing multiple non-invasive modalities, and the results will be compared among the three groups of CoA patients previously treated using surgery, balloon angioplasty or stent implantation after frequency matching for confounding variables. A comprehensive vascular function assessment protocol was created to be used in 7 centers. The primary outcome is arterial stiffness measured by arterial tonometry. Inclusion and exclusion criteria were carefully established after consideration of several potential confounders. Sample size was calculated for the primary outcome variable. Conclusions: Treatment modalities for CoA may have distinct impact on large and small arterial vascular function. The results of this study will help identify the treatment modality that is associated with the most optimal level of vascular function, which, in the long term may reduce CV risk.

NCT ID: NCT03147014 Recruiting - Clinical trials for Hypoplastic Left Heart Syndrome

Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease