Aortic Aneurysm Clinical Trial
Official title:
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"
The objective of this study is to establish whether patients with aortic aneurysm, compared to general population, have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in circulating blood and the size of the aortic aneurysm or the risk of its rupture.
Aneurysm of the abdominal and thoracic aorta represents a major cause of cardiovascular
morbidity and mortality. The course of this condition can stay asymptomatic for long, and
its first manifestation can be acute rupture of the aneurysm sac with life-threatening
bleeding. Detection of patients at risk and their early treatment significantly reduce the
percentage of this potentially lethal complications.
Aortic diseases are most often degenerative processes with a varying involvement of genetic
predisposition. In literature, a substantial number of genes were proved to affect the
metabolism of the vessel wall and to determine production of structural proteins, which were
associated with the vascular pathologies. Pathophysiologic mechanisms of lesions of the
aortic wall have not been completely understood. Among other, they include endothelial
dysfunction, chronic inflammation of the vessel wall, apoptosis of smooth muscle cells and
degradation of the extracellular matrix, resulting in the loss of integrity of layers of the
vessel wall and decrease in its strength, which leads to dilation, rupture or dissection.
Apart from mutations in genes coding the structural proteins of the vessel wall, many other
potential biomarkers were proposed for early diagnosis of aortic aneurysm. These include
microRNA (miRNA), one-fibre chains of non-coding ribonucleic acid which are several
nucleotides long and are involved in the gene expression through the mechanism of inhibition
of mRNA translation or increase in its degradation. Recently, association of levels of these
miRNAs to presence and growth of aortic aneurysms has been described.
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