Anticoagulation Clinical Trial
— KVADOfficial title:
Assessment of Coagulation Factor Levels in LVAD Patients Following Temporary Warfarin Reversal With 4F-PCC
Prospective assessment of vitamin K dependent coagulation factor levels after temporary warfarin reversal in participants with left ventricular assist devices (LAVD).
Status | Recruiting |
Enrollment | 50 |
Est. completion date | March 31, 2022 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - LVAD on warfarin requiring temporary interruption of anticoagulation for procedures Exclusion Criteria: - recent thrombotic event |
Country | Name | City | State |
---|---|---|---|
United States | Brigham and Women's Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Brigham and Women's Hospital | CSL Behring |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | plasma concentration of factors II,VII, IX, X, proteins S and C every 6 hours for 48 hours after treatment with 4F-PCC and correlation with international normalized ratio | assessment of change in vitamin K dependent coagulation factor levels after infusion of 4F-PCC | through 48 hours | |
Secondary | Adverse events | bleeding | 30 days | |
Secondary | adverse events | thrombosis | 30 days |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02705976 -
Prospective Trial of a Validated Algorithm for Warfarin Dosing
|
N/A | |
Active, not recruiting |
NCT04139525 -
Comparison of Citrate and Heparin Anticoagulation During Hemodialysis With MCO PES-PVP (Theranova) Membrane
|
N/A | |
Completed |
NCT01907048 -
Patient and Physician Knowledge of Key Safety Messages
|
||
Recruiting |
NCT03419923 -
Three Anticoagulation Strategies for Hemodialysis in Patients at Risk of Hemorrhage
|
N/A | |
Completed |
NCT03575936 -
Enhanced Pharmacist-Managed Anticoagulation Service in a University-based Family Medicine Clinic
|
N/A | |
Completed |
NCT02714855 -
Apixaban in the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation in Real-Life Setting in France
|
N/A | |
Recruiting |
NCT01314235 -
Influence of Clonidine on Thrombozytes of Blood of Patients Under Anticoagulation Therapy With ASS and Clopidogrel
|
N/A | |
Withdrawn |
NCT04059965 -
AntiCoagulation Tracking InterVention and Evaluation
|
N/A | |
Recruiting |
NCT02987192 -
Minimally Invasive Lumbar Aneasthesia Used for Cesarean Section
|
N/A | |
Completed |
NCT01477528 -
Study of Reduced Anti-coagulation/Anti-platelet Therapy in Patients With the HeartMate II Left Ventricular Assist System (LVAS) (TRACE)
|
||
Recruiting |
NCT04405232 -
Coagulopathy in COVID19 - A Multi-Centre Observational Study in UK
|
||
Recruiting |
NCT02761941 -
Excessive Warfarin Anticoagulation - Causes and Consequences
|
N/A | |
Completed |
NCT02392104 -
Prospective Evaluation of an Extended Interval of INR Follow-up in a VA Anticoagulation Service
|
N/A | |
Completed |
NCT01884337 -
Multi-center Study to Evaluate the Safety of Apixaban (BMS-562247) in Indian Subjects Undergoing Elective Total Knee Replacement or Total Hip Replacement Surgery
|
Phase 4 | |
Enrolling by invitation |
NCT05305612 -
Optimal PeriproCeduraL AnticOagulation in Structural Transseptal Interventions
|
Phase 4 | |
Completed |
NCT03662594 -
Growth of High-Quality Oxides on The Inner Surface of ECMO Circuit by ALD to Reduce Thrombus Formation
|
N/A | |
Active, not recruiting |
NCT03910933 -
Electronic KIDCLOT Interactive Thrombosis/Thrombophilia Education; A Quality Assurance Initiative
|
||
Completed |
NCT02492828 -
Adherence of Apixaban and Warfarin in Patients With Arterial Fibrillation in Real-world Setting in Sweden
|
N/A | |
Completed |
NCT03684395 -
Accessibility to New Drugs Versus SOC in Sweden
|
||
Completed |
NCT01124058 -
Evaluation of Maintenance Dosing vs Loading Dosing Upon Restarting Warfarin Therapy: A Prospective Randomized Trial
|
Phase 1 |