Anticoagulation Clinical Trial
Official title:
The Influence of Clonidine on the Thrombozytes of Patients Under Double Anticagulation With ASS and Clopidogrel - an in Vitro Study
Clonidin works as a presynaptic agonist of alpha-sympathomimetic receptors of the brain but
also in many other tissues. It is part of balanced anesthesia in general anesthesiology as
well as a sedastive agent in intensive care units, but also serves as a third-line agent in
many psychiatric diseases including ADHD, schizophrenia and PTSD.
The investigators want to show whether clonidin has an procoagulatoric effect on
thrombozytes of patients under double anticoagulaotirc treatment with ASS and clopidogrel.
The investigators will use a flowcytometric assay to determine activation of thrombozytes
when they come into contact with clonidine in vitro as well as Multiplate analyses to
determine activation of thrombozytes, either thrombin.induced aggregation, ADP-induced
aggregation or arachidonic acid-induced aggregation of thrombozytes.
n/a
Time Perspective: Prospective
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