Antibiotic Use Clinical Trial
Official title:
Can Change in Physicians' Prescribing Habits Decrease Carriage of Resistant Bacteria in the Community?
This study aims to implement judicious antibiotic prescription habits to primary care pediatricians using a multifacet educational intervention and assess two main outcomes: 1) Direct outcome - prescription rates of the physicians. 2)Indirect outcome - carriage of antibiotic resistant bacteria by the treated population, specifically nasopharyngeal S. pneumoniae, nasal S. aureus and rectal E.coli.
Background: Bacterial antibiotic resistance is an increasing problem.
Aims: This study aims to implement judicious antibiotic prescription habits among 30
physicians and their treated population as compared to a control group of 30 physicians and
their treated population. The outcomes to be measured are:
1. Change in antibiotic prescriptions to the treated patients of the intervention vs.
control physicians during the study period (4years).
2. Change in carriage of antibiotic resistant pathogens, specifically nasopharyngeal
penicillin resistant S. pneumoniae,nasal MRSA, and rectal quinolone resistant E. coli.
Study design: All primary care pediatricians of Hashfela district of Macabbi Healthcare
services who will agree to participate will be randomly assigned to an intervention or
control group. The intervention group will be led by local leaders (primary care physicians
from that district) and will take part in educational activities involving annual workshops
and quarterly focus group meetings. The intervention is a multifacet intervention that will
include guideline preparation, knowledge building, dealing with uncertainties, etc.
The patients of both intervention and control physicians will be screened twice a year for
carriage of the bacteria mentioned above. Cross-sectional screening of the treated
population will be carried in Summer and winter for 5 consecutive years. Screening will
include signing an informed consent, filling a questionnaire and screening with nasal,
nasopharyngeal and rectal swabs.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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