Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire

Antibiotic Reaction Clinical Trial

Official title:

Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04820062
• Other study ID #: 20CH031
• Status: Not yet recruiting
• Start date: August 2021
• Est. completion date: September 1, 2022

Study information

• Verified date: August 2021
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: GUILLAUME THIERY, MD PHD
• Phone: (0)4 77 12 78 53
• Email: guillaume.thiery[@]chu-st-etienne.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The current project represent phase 1 of the study : construction and validation of a questionnaire.

Description:

Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. In critical care setting, antibiotic therapies are widely used due to the high number of patients presenting with sepsis. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The study is designed to investigate social, cultural, contextual and personal factors influencing antibiotic prescribing among French intensivists. The design will consist of three phases:

• Phase 1: construction and validation of a questionnaire

• Phase 2: the questionnaire will be sent to all intensivist, including residents, in France

• Phase 3: qualitative study, based on semi-structured interviews.

The current project represent phase 1 of the study.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 115
• Est. completion date: September 1, 2022
• Est. primary completion date: September 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Physicians with predominant intensive care practice

• Resident, with a minimum of two-month experience in the intensive care unit

Exclusion Criteria:

• Refusal to participate

Related Conditions & MeSH terms

• Antibiotic Reaction

Intervention

Other:
• Content Validity
For the validity of built, it is generally advisable to include a ratio of 100 participants for 30 questionnaire items. In order to have a suitable questionnaire, we will limit ourselves to 30 items which will be the size of our questionnaire. It was therefore planned to include 100 participants The selection of experts will be based on experience in this area, knowledge and availability. It will be a rescimant physician and an infectious disease doctor. Each expert will be invited in isolation to comment on the items in the questionnaire

Locations

Country	Name	City	State
France	Chu St Etienne	Saint-Étienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Construct validity	qualitative study, based on semi-structured interviews.	months 18
Primary	Content validity	Construction and validation of a questionnaire by 2 experts in reanimation and infectiology.; This questionnaire will include these items: demographic datas, medical data concerning the use of antibiotics, social data exploring the collective and social components of antibiotic prescription, personal data in search of individual factors, attitude to antibiotic therapy.	months 18
Secondary	Face validity	the questionnaire will be sent to all intensivist, including residents, in France	months 18