Anti-Bacterial Agents Clinical Trial
Official title:
The Effects of Antibiotic Combinations on Mesenchymal Stem Cells Derived From Apical Papilla
NCT number | NCT04713436 |
Other study ID # | 2015-68 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2014 |
Est. completion date | February 1, 2017 |
Verified date | January 2021 |
Source | Eskisehir Osmangazi University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study was to evaluate the indirect effects of antibiotic combinations. SCAP viability, proliferation and apoptosis of the cells were evaluated. Osteocalcin (BGLAP), dentin sialo phosphoprotein (DSPP) and alkaline phosphatase (ALPP) gene expression levels were also evaluated.
Status | Completed |
Enrollment | 3 |
Est. completion date | February 1, 2017 |
Est. primary completion date | January 1, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 16 Years to 22 Years |
Eligibility | Inclusion Criteria: - Patients with open apex third molar teeth for extraction indication Exclusion Criteria: - Patients with mature apex third molar teeth for extraction indication |
Country | Name | City | State |
---|---|---|---|
Turkey | Eskisehir Osmangazi University | Eskisehir |
Lead Sponsor | Collaborator |
---|---|
Eskisehir Osmangazi University | TC Erciyes University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Measurment of Cell Viability and Apoptosis | To evaluate cell viability and apoptosis MuseCell Analyzer Count and Viability kit (Merck Millipore, Taufkirchen, Germany) was used according to the manufacturer's protocol. | 1 year | |
Primary | Measurment of cell differantiation | To determine gene expression levels, total RNA of SCAP was extracted using the Ambion PureLink RNA mini kit (Invitrogen, US) and the Roche cell RNA Kit (Penzberg, Germany) according to the manufacturer's instructions. | 1 year |
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