Anorexia Nervosa Clinical Trial
— HUSAANOfficial title:
Hunger and Satiety Perception in Patients With Anorexia Nervosa
Verified date | July 2016 |
Source | Odense University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Denmark: National Board of Health |
Study type | Observational |
Anorexia means loss of appetite. But there is disagreement about whether the appetite is
changed by the disease anorexia nervosa (AN). Appetite is a subjective essential sense,
which is regulated in a complex ensemble between brain, stomach - intestinal system and
hormones. As a direct result of malnutrition, there are many somatic complications caused by
the disease AN. Several of these complications may in itself affect hunger- and satiety
perception. An example of this is delayed gastric emptying. Furthermore, changes in the
hormone systems affects the biological "reward system" in the brain, which plays an
important role in appetite regulation. There is clearly need for research that could lead to
better treatments for AN. Hunger- and satiety perception has only been studied in a few
small cross-sectional studies with no clear conclusion.
The purpose of the study is to determine whether a visual analog scale measurement can
detect changes in hunger- and satiety perception in a least 30 patients admitted to
nutrition for life-threatening severe anorexia nervosa. It may lead to the first step in the
development of a simple and inexpensive instrument which may prove to be useful in measuring
the impact of new and ongoing treatments of the disease.
Status | Completed |
Enrollment | 47 |
Est. completion date | September 2016 |
Est. primary completion date | September 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 15 Years and older |
Eligibility |
Inclusion Criteria: - Patients with severe AN admitted to the specialized nutrition unit at Center for Eating disorders at Odense University Hospital are included. Exclusion Criteria: - Patients admitted only for short-term water-electrolyte correction, are excluded. |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Denmark | Center for eating Disorders, Odense University Hospital | Odense |
Lead Sponsor | Collaborator |
---|---|
Odense University Hospital |
Denmark,
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Dazzi F, Nitto SD, Zambetti G, Loriedo C, Ciofalo A. Alterations of the olfactory-gustatory functions in patients with eating disorders. Eur Eat Disord Rev. 2013 Sep;21(5):382-5. doi: 10.1002/erv.2238. Epub 2013 Jun 20. — View Citation
Doucet E, Imbeault P, St-Pierre S, Alméras N, Mauriège P, Richard D, Tremblay A. Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord. 2000 Jul;24(7):906-14. — View Citation
Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000 Jan;24(1):38-48. — View Citation
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Monteleone AM, Di Marzo V, Aveta T, Piscitelli F, Dalle Grave R, Scognamiglio P, El Ghoch M, Calugi S, Monteleone P, Maj M. Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. Am J Clin Nutr. 2015 Feb;101(2):262-9. doi: 10.3945/ajcn.114.096164. Epub 2014 Dec 10. — View Citation
Støving RK, Andries A, Brixen K, Flyvbjerg A, Hørder K, Frystyk J. Leptin, ghrelin, and endocannabinoids: potential therapeutic targets in anorexia nervosa. J Psychiatr Res. 2009 Apr;43(7):671-9. doi: 10.1016/j.jpsychires.2008.09.007. Epub 2008 Oct 15. Review. — View Citation
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---|---|---|---|---|
Primary | Hunger and satiety sensation | visual analogue scale | 30 minutes | No |
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