Anorexia Nervosa/Bulimia Clinical Trial
— FULLBR_ANBNOfficial title:
Exploring the Full Body Representation in Anorexia Nervosa and Bulimia Nervosa
NCT number | NCT06437002 |
Other study ID # | 49C403 |
Secondary ID | |
Status | Not yet recruiting |
Phase | |
First received | |
Last updated | |
Start date | June 15, 2024 |
Est. completion date | May 31, 2026 |
The ability to mentally recall a motor act without any overt movement is called motor imagery (MI). The movement simulation that occurs on a cognitive level can be seen as a way in which we express the mental representation of the body in action. MI tasks can be used as a proxy for the exploration of the mental representations of the body. Interestingly, MI tasks differ in the degree of action monitoring required to resolve the task. More in detail, we can allocate MI tasks along a continuum that goes from more implicit MI tasks (less action monitoring required for the resolution of the task) to more explicit MI tasks (more action monitoring required for the resolution of the task). Eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN) are both characterized by body image distortion and impairments (i.e. overestimation of the perceived body), however, on a different state of the physical body: on one hand we have a highly malnourished body, on the other hand, we might have a healthy-looking body or an overweight body. As above mentioned, MI tasks can be used as a proxy for the exploration of the mental representations of the body and people affected by AN and BN show impairment on their imagined body. This means that people affected by AN and BN might respond differently when assessed for their MI abilities. We hypothesize that people affected by AN might show greater impairment in their motor imagery abilities because of the greater discrepancy between the physical body (malnourished) and the mental body representation in comparison to people affected by BN, who usually have a health weight, even an altered body representation. Nevertheless, we might expect the alteration of body representation not strictly linked to the physical body dimensions, in the case of no difference between AN and BN. This would be of relevance for the creation of rehabilitative programs.
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | May 31, 2026 |
Est. primary completion date | June 15, 2025 |
Accepts healthy volunteers | |
Gender | Female |
Age group | 18 Years to 55 Years |
Eligibility | People affected by AN Inclusion Criteria: - Female; - age between 18 and 55 years old; - diagnosis of AN (restrictive and binge-purging type*), as per DSM V criteria (APA, 2013); - BMI = 17,5 Kg/m2; - right-handed (i.e. Edinburgh Handedness Inventory (EHI) (Veale, 2014)). - Restricting type: During the last 3 months, the individual has not engaged in recurrent episodes of binge eating or purging behaviour (i.e. self-induced vomiting or the misuse of laxatives, diuretics, or enemas). This subtype describes presentations in which weight loss is accomplished primarily through dieting, fasting, and/or excessive exercise. - Binge-eating/purging type: During the last 3 months, the individual has engaged in recurrent episodes of binge eating or purging behaviour (i.e. self-induced vomiting or the misuse of laxatives, diuretics, or enemas). Exclusion criteria: - presence of motor impairments, such as: motor disorders, broken limbs, inability to move, amputation of limbs, etc… because of the nature of the tasks - see the section Mental Motor Chronometry (MMC) Task Hands and Feet and Whole Body; - presence of neurological deficits, motor disorders, or somatosensory perception disorders (e.g. peripheral neuropathy); previous head injury; - schizophrenia spectrum disorders and other psychotic disorders on an acute phase; - pregnancy; - heavy use of medication because of acute symptoms. People affected by BN Inclusion Criteria: - female; - age between 18 and 55 years old; - diagnosis of BN, as per DSM V criteria (APA, 2013); - BMI = 17,5 Kg/m2 or BMI = 30 Kg/m2; - right-handed (i.e. EHI (Veale, 2014)). Exclusion criteria: - presence of motor impairments, such as: motor disorders, broken limbs, inability to move, amputation of limbs, etc… because of the nature of the tasks - see the section Mental Motor Chronometry (MMC) Task Hands and Feet and Whole Body; - presence of neurological deficits, motor disorders, or somatosensory perception disorders (e.g. peripheral neuropathy); previous head injury; - schizophrenia spectrum disorders and other psychotic disorders on an acute phase; - pregnancy; - heavy use of medication because of acute symptoms. HCs - enrolled voluntarily Inclusion Criteria: - female; - age between 18 and 55 years old; - right-handed (i.e. EHI (Veale, 2014)). Exclusion criteria: - history of eating disorders or obesity in the past 5 years and currently; - BMI = 17,5 Kg/m2 or BMI = 30 Kg/m2; - presence of motor impairments, such as: motor disorders, broken limbs, inability to move, amputation of limbs, etc… because of the nature of the tasks - see the section Mental Motor Chronometry (MMC) Task Hands and Feet and Whole Body; - presence of neurological deficits, motor disorders, or somatosensory perception disorders (e.g. peripheral neuropathy); previous head injury; - schizophrenia spectrum disorders and other psychotic disorders on an acute phase; - pregnancy; - heavy use of medication because of acute symptoms. Comparability between the four groups (AN restrictive vs AN binge-purging vs BN vs HCs) in terms of age and education will be guaranteed. |
Country | Name | City | State |
---|---|---|---|
Italy | istituto Auxologico italiano IRCSS | Milano | MI |
Lead Sponsor | Collaborator |
---|---|
Istituto Auxologico Italiano | Catholic University of the Sacred Heart, Heriot-Watt University, Open University, University of Turin, Italy |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mental Motor Chronometry (MMC) | Participants will watch a video of each movement and then will be asked to practice the movements. This will be followed by the MI condition for each body district. During the MI trials, participants will be asked to imagine performing the sequence of movements for each hand and each foot, five times, as quickly and as accurately as possible with their eyes closed. The whole-body movement trials will be imagined five times, but the block of trials will be repeated twice to ensure each body district is imagined the same number of times (e.g. imagery for the left limb was repeated for the right limb). After the MI condition participants will complete the motor execution task for each body district.
The order of the body district will be randomized between participants. For each participant and each body district, we will compute the average duration of the four movements for the right and the left side separately, both in the imagery and in the motor execution conditions. |
Immediately after the intervention/procedure |
Status | Clinical Trial | Phase | |
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