Ankylosing Spondylitis Clinical Trial
Official title:
Effects of Pilates Training on Respiratory Muscle Strenght in Patients With Ankylosing Spondylitis
NCT number | NCT03904953 |
Other study ID # | 43 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | April 2, 2019 |
Est. completion date | October 2, 2019 |
Background: Ankylosing Spondylitis (AS) is a chronic, inflammatory rheumatic disease that
effects primarily axial-spine. Reduction of flexibility and mobility is important factors
that can cause muscle weakness, impairment quality of life, reduction of exercise tolerance
and pulmonary capacity with the progression of AS. The purpose of this study is to
investigate the effects of pilates exercises on mobility, quality of life and respiratory
muscle strength in patients with AS.
Methods: Forty patients will be included who are aged between 18-55 years and got diagnosed
according to Modified New York criterias.Patients will be divided into two groups randomly.
Pilates training will be performed to the treatment group and conventional exercises will be
performed to the control group during 8 weeks. Respiratory muscle strength, quality of life,
spinal mobility, thorax expansion, respiratory functions, physical activity level, exercise
capasity and disease activity will be evaluated at first session and at the end of the 8th
week in this study.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | October 2, 2019 |
Est. primary completion date | June 2, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 55 Years |
Eligibility |
Inclusion Criteria: - Patients who are aged between 18-55 years, - Patients who got diagnosed according to Modified New York criteria - Patients who are being followed at Gazi University Department of Rheumatology. Exclusion Criteria: - Patients who have exercise habits - Incooperation - Malignancy - Pregnancy - Patients who have changes of medical treatment in the last 3 months - Patients who have another disease that can effect pulmonary functions |
Country | Name | City | State |
---|---|---|---|
Turkey | Gazi University | Ankara |
Lead Sponsor | Collaborator |
---|---|
Gazi University |
Turkey,
Altan L, Korkmaz N, Dizdar M, Yurtkuran M. Effect of Pilates training on people with ankylosing spondylitis. Rheumatol Int. 2012 Jul;32(7):2093-9. doi: 10.1007/s00296-011-1932-9. Epub 2011 Apr 17. — View Citation
Rosu MO, Topa I, Chirieac R, Ancuta C. Effects of Pilates, McKenzie and Heckscher training on disease activity, spinal motility and pulmonary function in patients with ankylosing spondylitis: a randomized controlled trial. Rheumatol Int. 2014 Mar;34(3):367-72. doi: 10.1007/s00296-013-2869-y. Epub 2013 Sep 26. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Respiratory muscle strength | Respiratory muscle strength will be assessed by digital mouth-pressure meter (Micro Medical MicroRM, Rochester, England). Maksimal inspiratory pressure (MIP) and Maksimal Expiratory Pressure (MEP) will be measured with the subject sitting and breathing through a mouthpiece by encouraged verbally, after clamping the nose (cmH2O). To measure MIP, the patient will be requested to breath in quickly and deeply until total lung capacity, just after breath out maximally until residual volume. To measure MEP, the patient will be requested to breath until total lung capacity and then breath out quickly until residual volume. Leaks around the mouthpiece will be avoided. The best of five attempts will be selected and stated as percent of expected values according to sex and age | 5 minutes | |
Secondary | Bath Ankylosing Spondylitis Metrology Index | Spinal mobility will assessed and scored by Bath Ankylosing Spondylitis Metrology Index (BASMI). There are five measurements including lateral lumbar flexion, tragus-to-wall distance, lumbar flexion (Modified Schober), maximal intermalleolar distance and cervical rotation according to the index. Each subscale is scored between 0 and 10. All points are then averaged to calculate total score. Higher values represent worse outcomes. | 5 minutes | |
Secondary | Ankylosing Spondylitis Quality of Life Questionnaire | Quality of life will be assessed with Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) which has 18 items, each with response True/Not True. 'True responses are summed to create a total score. High scores mean poor quality of life | 1 minute | |
Secondary | Thorax pain | Visual Analog Scale (VAS) will be used to determine the intensity of thorax pain; 0 means 'no pain' while 10 means 'unbearable pain'. | 1 minute | |
Secondary | Chest expansion | Chest expansion will be measured with a tape placed circumferentially around the chest wall (axillar, subcostal, epigastric) in cm. | 2 minutes | |
Secondary | Aerobic capacity | Aerobic capacity will be assessed with 6 minute walk test (6MWT) which is a submaximal effort test. 6MWT is a distance required to fast-paced walk on flat floor in length 30 meters. The aim of the 6MWT is to walk as long as the patient can walk in 6 minutes. Dyspnoea and fatigue level are recorded at the end of the test. Distance covered by the patient is calculated at the of 6 minutes | 10 minutes | |
Secondary | Bath Ankylosing Spondylitis Disease Activity Index | Bath Ankylosing Spondylitis Disease Activity Index which consists of 6 questions will be used to evaluate disease activity. BASDAI is a composite index, consisting of an assessment on a 10 cm horizontal visual analog scale of fatigue, axial pain, peripheral pain, enthesopathy and stiffness. Fifth and sixth questions are averaged. Addition to this score, other questions are averaged. Total score is between 0 and 10. Higher score represent worse outcome. | 1 minute | |
Secondary | International Physical Activity Questionnaire- Short Form | This questionnaire obtains information about how much time is spent while walking and in moderate and vigorous activities and sitting duration in the last 7 days. The questionnaire records the activity of four intensity levels: 1) vigorous-intensity activity, 2) moderate-intensity activity, 3) walking, and 4) sitting. Durations are multiplied by known METs per activity and the results for all items are summed for the overall physical activity score. Scores for walking and for moderate and vigorous activities are sums of corresponding item scores. A sitting question is not included in physical activity score. The questionnaire is scored as: those who score high on the IPAQ engage in vigorous intensity activity of at least 1500 MET minutes a week, those who score modarete on the IPAQ of at least 600 MET minutes a week, those who score a low level of physical activity on the IPAQ means that not meeting any of the criteria for either moderate or high levels of physical activity | 1 minute |
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