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Clinical Trial Summary

To find the highest tolerable dose of an mRNA vaccine that can be safely given to patients with cutaneous angiosarcoma


Clinical Trial Description

Objectives: Primary objective: •To determine the safety, toxicity, and feasibility of delivering autologous dendritic cells (DCs) loaded with tumor lysate plus mRNA to patients with cutaneous head & neck angiosarcoma as adjuvant therapy. Secondary objective: • To assess the recurrence free survival and overall survival in treated patients in order to make initial assessment of activity of this therapeutic approach Exploratory Objectives: • To quantitate immune responses in patients who receive autologous DCs loaded with tumor lysate plus mRNA ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05799612
Study type Interventional
Source M.D. Anderson Cancer Center
Contact Vinod Ravi, MD
Phone (713) 792-1641
Email vravi@mdanderson.org
Status Recruiting
Phase Phase 1
Start date March 22, 2024
Completion date December 31, 2029

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