Angina in Non Coronary Artery Disease

Angina Pectoris Clinical Trial

— HeartQuest  

Official title:

Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01318629
• Other study ID #: Heart Quest
• Status: Active, not recruiting
• Phase: N/A
• First received: March 17, 2011
• Last updated: April 16, 2013
• Start date: July 1996
• Est. completion date: July 2018

Study information

• Verified date: April 2013
• Source: Luzerner Kantonsspital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Observational

Clinical Trial Summary

Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

Description:

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 718
• Est. completion date: July 2018
• Est. primary completion date: July 2018
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008

• No significant coronary stenoses (no coronary stenoses = 50%)

Exclusion Criteria:

• Severe valvular heart disease

• Severe congestive heart failure

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Angina Pectoris
• Angina Pectoris, Variant
• Microvascular Angina

Locations

Country	Name	City	State
Switzerland	Luzerner Kantonsspital	Luzern

Sponsors (1)

Lead Sponsor	Collaborator
Luzerner Kantonsspital

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cause of angina equivalent symptoms in patients with no coronary artery disease		One day	No
Primary	Prognosis of patients with angina equivalent symptoms and normal coronary arteries		10 years after baseline assessment	No