Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Angina Pectoris Clinical Trial

Official title:

Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00184444
• Other study ID #: 094-2004
• Status: Completed
• Phase: N/A
• First received: September 15, 2005
• Last updated: July 19, 2016
• Start date: September 2004
• Est. completion date: July 2007

Study information

• Verified date: July 2016
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Norwegian Social Science Data Services
• Study type: Interventional

Clinical Trial Summary

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured.

The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: July 2007
• Est. primary completion date: July 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• stable angina pectoris age 18-75

Exclusion Criteria:

• unstable angina pectoris

• Limitations to exercise other than coronary artery disease

• Participants in other study interventions

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Angina Pectoris
• Angina, Stable

Intervention

Behavioral:
• Hypoxic interval training
4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max
• Normoxic interval training
4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max

Locations

Country	Name	City	State
Norway	Norwegian University of Science and Technology	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	Aarhus University Hospital

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Karlsen T, Hoff J, Støylen A, Skovholdt MC, Gulbrandsen Aarhus K, Helgerud J. Aerobic interval training improves VO2 peak in coronary artery disease patients; no additional effect from hyperoxia. Scand Cardiovasc J. 2008 Oct;42(5):303-9. doi: 10.1080/1401 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	maximal oxygen uptake		Baseline and post training	No
Secondary	Cardiac perfusion		Baseline and post training	No
Secondary	work economy		Baseline and post training	No
Secondary	cardiac output		baseline and post training	No