Anesthetic Toxicity Clinical Trial
Official title:
The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children
The concentration of folic acid and homocysteine in the blood can be used as independent risk factors for a variety of diseases. A sustained decrease in blood folate concentration and an increase in homocysteine concentration can damage vascular endothelial cells, causing varying degrees of neurodevelopmental abnormalities. Many clinical studies have found that anesthetics can affect blood folate and homocysteine concentration, but the effects of sevoflurane and propofol on blood folate and homocysteine concentrations are not clear. Therefore, this study aims to investigate the effects of sevoflurane and propofol on blood folate and homocysteine levels in children.
Retrospective study: Study the medical history of infants and young children (less than 3
years old) who underwent sevoflurane or propofol general anesthesia for more than 3 hours
from January 2018 to December 2018, and compare the preoperative and postoperative serum
folate changes for retrospective analysis.
Prospective study：Ten infants and young children (less than 3 years old) who underwent
general anesthesia from November 7, 2018 to December 31, 2018 in Shanghai Ninth People's
Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Inhalation of 1-8%
concentration of sevoflurane for general anesthesia induced intubation, followed by
sevoflurane 2.0 ~ 2.5 Vol% inhalation maintenance, according to the intraoperative situation
to add opioids. Patients maintained a bispectral index (BIS) monitoring between 50 and 60.
After induction of general anesthesia in all patients, Serum folate levels were measured
before the start of surgery, every 1 hour during surgery, and at the end of surgery.
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