Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05185167
Other study ID # MSKU 05/III
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 17, 2022
Est. completion date March 20, 2022

Study information

Verified date March 2022
Source Mugla Sitki Koçman University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.


Description:

It is expected that DNA damage information provide the possible genotoxic effects of inhalational and intravenous anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed patients.


Recruitment information / eligibility

Status Completed
Enrollment 30
Est. completion date March 20, 2022
Est. primary completion date March 15, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: 1. Ability to understand and willingness to sign an informed consent form 2. Elective lumbar spinal surgery that will take at least 120 minutes, 3. American Society of Anesthesiologists (ASA) physical status I and II Exclusion Criteria: 1. Patients with ASA physical status III or IV disease 2. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders) 3. Smoking or alcohol consumption 4. Recently received radiation, chemotherapy 5. Malignancy 6. Patients who will receive blood transfusion during the operation 7. Users of antioxidant supplements 8. Patients who have received general anesthesia in the last three months 9. Patients with known occupational exposures (operating room personnel, chemical plant worker

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Anesthetics, General Desflurane Maintenance
Comparison of dna damage of desflurane maintenance with propofol maintenance according to comet analysis
Anesthetics, General Propofol Maintenance
Comparison of dna damage of propofol maintenance with desflurane maintenance according to comet analysis

Locations

Country Name City State
Turkey Mugla Sitki Kocman University Mugla

Sponsors (1)

Lead Sponsor Collaborator
Mugla Sitki Koçman University

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. Before anesthesia induction
Primary Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. 2 hours after anesthesia induction
Primary Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. postoperative 1st day
Primary Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. postoperative 5th day
Primary Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. Before anesthesia induction
Primary Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. 2 hours after anesthesia induction
Primary Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. postoperative 1 st day
Primary Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. postoperative 5th day
Primary Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. before anesthesia induction
Primary Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. 2 hours after anesthesia induction
Primary Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. postoperative 1 st day
Primary Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. postoperative 5th day
See also
  Status Clinical Trial Phase
Active, not recruiting NCT04580030 - Tricuapid Annular Plane Sistolic Excursion Before General Anesthesia Can Predict Hypotension After Induction
Active, not recruiting NCT04279054 - Decreased Neuraxial Morphine After Cesarean Delivery Early Phase 1
Completed NCT03640442 - Modified Ramped Position for Intubation of Obese Females. N/A
Recruiting NCT04099693 - A Prospective Randomized Study of General Anesthesia Versus Anesthetist Administered Sedation for ERCP
Terminated NCT02481999 - Pre- and Postoperative EEG-Monitoring for Children Aged From 0,5 to 8 Years
Completed NCT04235894 - An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia
Recruiting NCT05525104 - The Effect of DSA on Recovery of Anaesthesia in Children (Het Effect Van DSA op Het Herstel na Anesthesie Bij Kinderen). N/A
Recruiting NCT05024084 - Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth Phase 4
Completed NCT04204785 - Noise in the OR at Induction: Patient and Anesthesiologists Perceptions N/A
Completed NCT03277872 - NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope N/A
Terminated NCT03940651 - Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4
Terminated NCT02529696 - Measuring Sedation in the Intensive Care Unit Using Wireless Accelerometers
Completed NCT05346588 - THRIVE Feasibility Trial Phase 3
Terminated NCT03704285 - Development of pk/pd Model of Propofol in Patients With Severe Burns
Recruiting NCT05259787 - EP Intravenous Anesthesia in Hysteroscopy Phase 4
Completed NCT02894996 - Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient? N/A
Completed NCT05386082 - Anesthesia Core Quality Metrics Consensus Delphi Study
Terminated NCT03567928 - Laryngeal Mask in Upper Gastrointestinal Procedures N/A
Recruiting NCT06074471 - Motor Sparing Supraclavicular Block N/A
Completed NCT04163848 - CARbon Impact of aNesthesic Gas