Anesthesia Clinical Trial
Official title:
Genotoxic Effects of Desflurane and Propofol Anesthesia in Patients Undergoing Lumbar Disc Surgery
Verified date | March 2022 |
Source | Mugla Sitki Koçman University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.
Status | Completed |
Enrollment | 30 |
Est. completion date | March 20, 2022 |
Est. primary completion date | March 15, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: 1. Ability to understand and willingness to sign an informed consent form 2. Elective lumbar spinal surgery that will take at least 120 minutes, 3. American Society of Anesthesiologists (ASA) physical status I and II Exclusion Criteria: 1. Patients with ASA physical status III or IV disease 2. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders) 3. Smoking or alcohol consumption 4. Recently received radiation, chemotherapy 5. Malignancy 6. Patients who will receive blood transfusion during the operation 7. Users of antioxidant supplements 8. Patients who have received general anesthesia in the last three months 9. Patients with known occupational exposures (operating room personnel, chemical plant worker |
Country | Name | City | State |
---|---|---|---|
Turkey | Mugla Sitki Kocman University | Mugla |
Lead Sponsor | Collaborator |
---|---|
Mugla Sitki Koçman University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. | Before anesthesia induction | |
Primary | Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. | 2 hours after anesthesia induction | |
Primary | Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. | postoperative 1st day | |
Primary | Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the intensity of the DNA tail, and the tail greater, the greater the damage. | postoperative 5th day | |
Primary | Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. | Before anesthesia induction | |
Primary | Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. | 2 hours after anesthesia induction | |
Primary | Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. | postoperative 1 st day | |
Primary | Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the head length of DNA, the head greater, the smaller the damage. | postoperative 5th day | |
Primary | Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. | before anesthesia induction | |
Primary | Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. | 2 hours after anesthesia induction | |
Primary | Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. | postoperative 1 st day | |
Primary | Tail length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire | The blood samples that evaluate with comet analysis aim to detect the tail length of DNA, the head greater, the greater the damage. | postoperative 5th day |
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