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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05177159
Other study ID # 2018-5-30
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date November 10, 2018
Est. completion date December 30, 2023

Study information

Verified date February 2023
Source Beijing Tiantan Hospital
Contact Zhengfang Hu, M.D., Ph.D
Phone 8610-67096658
Email huzhengfang78@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Postoperative delirium (POD) is a common complication in elderly patients and is associated with negative clinical outcomes, such as prolonged hospitalizations, cognitive impairment, and higher mortality rate. While the pathophysiology of delirium remains unknown, the cerebral hypoperfusion and neuroinflammatory response are considered to play an important role in the process of POD. The aim of the study is to determine the association between POD and biomarkers in elderly patients undergoing noncardiac and non-neurological surgery.


Recruitment information / eligibility

Status Recruiting
Enrollment 417
Est. completion date December 30, 2023
Est. primary completion date December 30, 2023
Accepts healthy volunteers No
Gender All
Age group 60 Years to 85 Years
Eligibility Inclusion Criteria: - With American Society of Anesthesiologists (ASA) physical status ?-? - Undergo elective non-cardiac and non-neurological surgery receiving general anesthesia - Operation time is expected to be longer than 2 hours Exclusion Criteria: - Clinical diagnosis of dementia - Clinical diagnosis of cerebrovascular disorders - Clinical diagnosis of heart failure - Clinical diagnosis of liver failure - Clinical diagnosis of renal failure - Clinical diagnosis of traumatic brain injury - Alcohol abuse - Can not complete the cognitive assessments - Refuse to sign informed consent

Study Design


Related Conditions & MeSH terms


Intervention

Other:
The regional cerebral oxygen saturation (rSO2)
Measurement of rSO2 with non-invasive near-infrared light spectrum monitor. The average, left and right frontal regions absolute rSO2 values will be collected every 30 seconds during the whole surgery until postoperative 2 hours, and the mean values will be calculated. Absolute rSO2 value and AUT (area under the threshold) send beneath the absolute threshold limits of 40%, 50% and 20%, 30% under the baseline. AUT will be calculated based on this formula: AUT (present)=AUT (past)+(rSO2 threshold-rSO2 value)×sample rate
The glial fibrillary acidic protein (GFAP)
Venous blood sample will be collected and tested for plasma GFAP. The blood will be collected 10 minutes before anesthesia, 30 minutes after intubation, every hour during operation, 15 minutes after extubation, and at 10:00 AM in postoperative 1,3,5 days.
The brain-derived-neurotrophic factor (BDNF)
Venous blood sample will be collected and tested for plasma BDNF. The blood will be collected 10 minutes before anesthesia, 30 minutes after intubation, every hour during operation, 15 minutes after extubation, and at 10:00 AM in postoperative 1,3,5 days.

Locations

Country Name City State
China Beijing Tiantan Hospital Beijing Beijing

Sponsors (1)

Lead Sponsor Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary The incidence of postoperative delirium within postoperative 5 days The postoperative delirium will be diagnosed if patients have fluctuation in mental status and attention and either thinking or consciousness in the past 24 hours as evidenced by fluctuation on Confusion Assessment Method-Intensive Care Unit (CAM-ICU) scale. the incidence of delirum within postoperative 5 days.
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