Expired Propofol in Low Back Surgery

Status Recruiting

Clinical Trial Summary

Edmon (BBraun, Germany) is a portable, commercially available device for measurement of propofol in exhaled air. The study will aim at evaluating the sensitivity and specificity of such exhaled propofol values compared with plasma propofol and measures of anaesthetic and antinociceptive effect.

Clinical Trial Description

Elective low-back surgery patients will be induced for general intubation anesthesia with propofol and remifentanil. After induction a 20 min period of stable propofol infusion only will be established before start of surgery. The patients will be monitored for exhaled propofol, plasma propofol (blood samples), continous frontal EEG, Bispectral Index (BIS), skin conductance, estimated (computer based) concentrations of plasma and effect site propofol, and skin conductance. After start of surgery (with ongoing propofol and restart of remifentanil TCI) the monitoring will continue in order to explore these relationships further. ;

Study Design

Related Conditions & MeSH terms

Anesthesia

Clinical Trial Details

NCT number	NCT04771702
Study type	Interventional
Source	Oslo University Hospital
Contact	Johan Raeder, PhD
Phone	004792249669
Email	johan.rader@medisin.uio.no
Status	Recruiting
Phase	N/A
Start date	January 14, 2021
Completion date	December 2024

View Details

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