The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Status Completed

Clinical Trial Summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Clinical Trial Description

Background

Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.

Objective

The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.

Methods

Cross-sectional association study in a cohort of non-cardiac surgery patients.

This study is a Subproject of a prospective cohort study registered under the ID 041/09. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04327258
Study type	Observational
Source	University Hospital Inselspital, Berne
Contact
Status	Completed
Phase
Start date	January 2011
Completion date	December 2014

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