Anesthesia Clinical Trial
Official title:
A Comparison of Two Different Anesthetic Application (Sedation / Analgesia & LMA) on Anxiety Level and Patient Satisfaction in Patients With in Vitro Fertilization: Prospective Randomized Clinical Trial
In vitro fertilization (IVF) is a new expertise of our age. Anesthesia during the assisted
reproduction technique is usually required during oocyte removal, which is one of the basic
steps throughout the entire procedure. Until now, different anesthetic techniques such as
conscious sedation, general anesthesia and regional anesthesia have been tried, no
superiority has been proved against each other. The main point of anesthesia management in
IVF is to minimize anesthesia exposure to avoid harmful effects on embryo division and
fertilization.
The aim of this prospective randomized clinical trial was to compare two different anesthesia
applications (sedation & laryngeal mask airway) on anxiety and patient satisfaction in
patients with IVF.
In vitro fertilization (IVF) is a new expertise of our age. Anesthesia during the assisted
reproduction technique is usually required during oocyte removal, which is one of the basic
steps throughout the entire procedure. Until now, different anesthetic techniques such as
conscious sedation, general anesthesia and regional anesthesia have been tried, no
superiority has been proved against each other. The main point of anesthesia management in
IVF is to minimize anesthesia exposure to avoid harmful effects on embryo division and
fertilization.
IVF requires the collection of mature oocytes from the ovaries of infertile patients. These
oocytes are then fertilized in vitro and allowed to become embryos. Afterwards, these embryos
are transferred into the uterus of the patients. Ultrasonography-guided transvaginal
aspiration makes oocyte intake less invasive compared to prior techniques and can be
administered within 30 minutes. With the development of this method, trauma was minimalized
and side effects were reduced. However, the possible effects of different anesthetics on
oocytes are still being discussed. The potential side effects of different anesthesia
applications have been observed not only in patients receiving oocytes, but also in embryo
development and pregnancy success due to the quality of oocytes. The pain of patients is
common after the puncture of the vaginal fornix. It is usually defined as deep menstrual
pain, quickly disappears and leaves a mild abdominal pain. Therefore, the anesthetist should
perform adequate pain relief to immobilize the patient to avoid the risk of perforating the
vessels during the procedure. Another challenge for the anesthesiologist is to alleviate the
increased anxiety associated with social and psychological stress associated with IVF.
Anxiety may develop before and after the procedure, especially in patients undergoing oocyte
collection. The patient's anxiety is usually present before entering the operating room. The
assessment, which was started to be developped by investigators, was aimed to measure state
anxiety levels in normal and non-normal individuals. State-Trait Anxiety Inventory measures
state anxiety levels and is an easy-to-implement inventory that the individual can answer on
his/her own. The State Anxiety Scale determines how the individual feels himself / herself at
a given moment and under certain conditions. It is widely used in preoperative anxiety
measurement.
Patient satisfaction depends on the patient's expectations and the benefits expected by the
patients with the service they receive. Patient satisfaction is the result of meeting the
wishes and expectations of the patients. An investigator has developed the Recovery Quality
Score-40 (Quality of Recovery Score) and is used to measure the quality of postoperative
recovery. This form consists 40 items and is divided into 5 subgroups according to various
aspects of the improvement. There are a total of 40 items, 9 related to emotional state, 12
related to physical comfort, 7 related to psychological support, 5 related to physical
independence and 7 items related to pain. The questionnaire is scored as a minimum of 40 to a
maximum of 200. No special training is required for the implementation of the survey. The
fact that the patient can perform the survey on his own and can be done in a short time gives
a significant advantage.
The aim of this prospective randomized clinical trial was to compare two different anesthesia
applications (sedation & laryngeal mask airway) on anxiety and patient satisfaction in
patients with IVF.
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