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NCT03335579 Clinical Trial

General Anesthetic Mode and Postoperative Complications

Anesthesia Clinical Trial

Official title:
Relationship Between General Anesthetic Mode and Postoperative Severe Cardiovascular and Cerebrovascular Complications: a Retrospective Cohort Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03335579
Other study ID # GATCIMACE
Secondary ID
Status Completed
Phase N/A
First received October 30, 2017
Last updated November 3, 2017
Start date December 31, 2016
Est. completion date October 10, 2017

Study information
Verified date November 2017
Source Peking University First Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The relationship between anesthetic medication and postoperative major cardiac and cerebral complications will be studied using logistic regression model.

Description:

The study group try to find out if there is a connection between the use of different anesthetic methods with different narcotic drugs and postoperative major cardiac and cerebral complications.

Recruitment information / eligibility
Status Completed
Enrollment 50000
Est. completion date October 10, 2017
Est. primary completion date August 1, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- non-cardiac surgery, with age> = 18 years old, ASA grade I-IV, under general anesthesia

Exclusion Criteria:

- non-general anesthesia, without the use of target-controlled infusion of remifentanil or sufentanil, absence of intraoperative or perioperative information.

Study Design

Related Conditions & MeSH terms

Intervention

Combination Product:
• inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil
Different combination of opioids and anesthetics

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Peking University First Hospital

References & Publications (4)

Flier S, Post J, Concepcion AN, Kappen TH, Kalkman CJ, Buhre WF. Influence of propofol-opioid vs isoflurane-opioid anaesthesia on postoperative troponin release in patients undergoing coronary artery bypass grafting. Br J Anaesth. 2010 Aug;105(2):122-30. doi: 10.1093/bja/aeq111. Epub 2010 Jun 23. — View Citation

Güçlü ÇY, Ünver S, Aydinli B, Kazanci D, Dilber E, Özgök A. The effect of sevoflurane vs. TIVA on cerebral oxygen saturation during cardiopulmonary bypass--randomized trial. Adv Clin Exp Med. 2014 Nov-Dec;23(6):919-24. doi: 10.17219/acem/37339. — View Citation

Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Møller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4:CD011387. doi: 10.1002/14651858.CD011387.pub2. Review. — View Citation

Min JJ, Kim G, Lee JH, Hong KY, Kim WS, Lee YT. Does the Type of Anesthetic Technique Affect In-Hospital and One-Year Outcomes after Off-Pump Coronary Arterial Bypass Surgery? PLoS One. 2016 Apr 7;11(4):e0152060. doi: 10.1371/journal.pone.0152060. eCollection 2016. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Major cardiac complication major cardiac event 90 days after surgery
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