Anesthesia Clinical Trial
— RCVBOfficial title:
Comparison of Hourly Rocuronium Consumption Using Continuous Infusion Versus Intermittent Bolus Injection: a Randomized Controlled Trial
The research is to find out whether continuous infusion of rocuronium requires more or less amount of rocuronium, per kilogram and per hour, than bolus administered rocuronium during noncardiac surgery.
Status | Recruiting |
Enrollment | 70 |
Est. completion date | March 2018 |
Est. primary completion date | November 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Years to 12 Years |
Eligibility |
Inclusion Criteria: - Pediatric patients aged between 2 and 12, undergoing elective noncardiac surgery which requires general anesthesia but does not require intense block, and estimated time of surgery is between 2 and 5 hours Exclusion Criteria: - ASA class 3-6 - BMI >= 30 - Previous history of hepatic failure, renal failure or neuromuscular disease - Patients taking medicine which interacts with rocuronium bromide, before or during surgery: aminoglycosides, lincosamides, acylamino-penicillin antibiotics, tetracyclines, metronidazole (high dose), diuretics, MAO inhibitors, calcium channel blockers, corticosteroids, phenytoin, carbamazepine, or norepinephrine - Previous history of allergic reaction (including anaphylactic reaction) and/or malignant hyperthermia during general anesthesia - Patients taking medicines which contains magnesium |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | SNUH | Seoul | Jongro Gu |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rocuronium dose per kilogram per hour | Total dose of rocuronium injected during surgery, divided by patient body weight and anesthesia time. | end of the surgery | |
Secondary | Desaturation event | Whether the participant's peripheral oxygen saturation (SpO2) decreased less than 93%, in postanesthesia care unit (PACU). | Right after the patient is transferred to the ward, from PACU (1 day) | |
Secondary | Surgical rating scale | Numerical scale describing how easy it is for surgeon to access surgical field, ranging from1 to 5 | end of the surgery |
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