Anesthesia Clinical Trial
Official title:
Electroencephalographic Profiles During General Anesthesia : a Comparative Study Between Sevoflurane and Propofol.
A cerebral pharmacodynamic feedback may help the anesthesiologist to adjust anesthetics
administration. The BIS, which provides a single number resulting from an algorithm
calculated from cortical EEG parameters, may play this role.Moreover, halogenated agents and
propofol may have different EEG effects, which might interfere on measured BIS values.
The aim of this prospective randomized study was to compare, in steady state conditions, the
EEG profiles in children anesthetized with sevoflurane (S) or propofol (P) : for both
anesthetics, the BIS-concentration relationship and raw EEG were analysed at different levels
of general anesthesia.
Children will be prospectively included and randomly assigned in two groups : Propofol (P)
Group or Sevoflurane (S) Group.
Steady state periods will be performed at a fixed randomized concentration between 2, 3, 4, 5
and 6 mcg/ml of stable Ct P concentration in the P group and between 1,2,3,4,5 % of FeS in
the S group.
At the end of each steady-state period the BIS value was noted and the relationship between
BIS and anesthetic concentrations will be studied using non linear regression. For all steady
state periods, EEG traces will be reviewed to determine the presence of epileptiform signs
(ES) and spectral EEG signal analysis with fast Fourier transformation (FFT) will be
performed.
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