Comparison of Analgesic Effect of Volatile Anesthetics

Anesthesia Clinical Trial

Official title:

The Comparison of Analgesic Effect of Volatile Anesthetics Using Surgical Pleth Index

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02830243
• Other study ID #: 2016-05-058
• Status: Completed
• Phase: Phase 3
• Start date: July 12, 2016
• Est. completion date: October 8, 2016

Study information

• Verified date: May 2018
• Source: Kangbuk Samsung Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.

Description:

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: October 8, 2016
• Est. primary completion date: October 5, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil

• patients with american society of anesthesiologist physical status I, II

• patients aged 19-65 years

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease

• patients who had received any medication affecting the central nervous system

• patients who had received medication affecting the sympathetic or parasympathetic nervous systems

• patients undergoing tracheal intubation for airway management

• pregnant women

Related Conditions & MeSH terms

• Anesthesia

Intervention

Drug:
• Sevoflurane
End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.
• Desflurane
End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.

Locations

Country	Name	City	State
Korea, Republic of	Kangbuk Samsung Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Kangbuk Samsung Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Remifentanil consumption (µg/kg/min)		During the intraoperative period
Secondary	Target effective site concentration of remifentanil (ng/ml)		After at least 10 min of stable surgical pleth index values