Anesthesia Clinical Trial
Official title:
The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy
Verified date | July 2017 |
Source | Ajou University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown
to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may
increase patient discomfort, delay patient discharge, and increase the cost of patient care,
the risk of postoperative bleeding which may potentially cause airway obstruction.
It is reported that the maintenance of anesthesia with propofol-remifentanil or
sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone,
but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in
patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3
antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly
during this period.
The purpose of this study was to evaluate and compare the incidence of PONV after
thyroidectomy with three different anesthetic methods, sevoflurane or
sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman
patients.
Status | Completed |
Enrollment | 150 |
Est. completion date | April 20, 2017 |
Est. primary completion date | April 20, 2017 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - patients undergoing thyroidectomy euthyroid status American Society of Anesthesiology Physical status 1,2 Exclusion Criteria: - Ideal body weight >130% gastrointestinal disease prior administration of anti-emetics (24hr) |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Ajou universiry hospital | Suwon | Gyeonggi-do |
Lead Sponsor | Collaborator |
---|---|
Ajou University School of Medicine | CJ HealthCare Corporation |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | incidence of postoperative nausea and vomiting | 24 hour postoperative | ||
Secondary | incidence of postoperative nausea and vomiting | at immediate postoperative | ||
Secondary | incidence of postoperative nausea and vomiting | 6 hour postoperative | ||
Secondary | incidence of postoperative nausea and vomiting | 48 hour postoperative |
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