Anesthesia Clinical Trial
Official title:
Assessment of Preoxygenation Strategies in the Prehospital Environment
Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.
Prospective randomised interventional study.
Healthy volunteers will be positioned supine and undergo preoxygenation by tidal volume
breathing for 3 minutes using each technique in turn. The sequence of techniques for each
volunteer will be randomised in advance. Investigators will be instructed to ensure a good
mask seal throughout the testing period. At the end of a 3 minute preoxygenation period,
after a brief breath hold, the volunteer will exhale into reservoir tubing, allowing the
fractional expired oxygen concentration (FeO2) to be determined (primary outcome) using a
calibrated gas analyser.
The techniques being assessed have been chosen from methods of preoxygenation commonly
available to clinicians in the prehospital environment:
1. Continuous Positive Airway Pressure mode with fractional inspired oxygen concentration
(FiO2) 100% using a portable ventilator.
2. Bag-valve-mask device (BVM) with 15 l/min oxygen flow.
3. Non-rebreather mask (NRM) device with 15 l/min oxygen flow.
Volunteers will also be asked to indicate the subjective ease of breathing for each
technique (secondary outcome) using a visual analogue scale (VAS).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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