Anesthesia Clinical Trial
Official title:
Effect of Phenylephrine Infusion for Preventing Hypotension During Shoulder Arthroscopic Surgery in the Beach Chair Position
The purpose of this study is to determine whether phenylephrine infusion are effective in
the prevention of hypotension after changing position to beach chair position during general
anesthesia for shoulder arthroscopic surgery.
Investigators hypothesized that by increasing arterial blood pressure with phenylephrine
infusion, incidence of hypotension would be decreased.
The beach chair position is associated with hypotension, risk of cerebral hypoperfusion, and
cerebral injury. Sixty-six patients undergoing elective shoulder arthroscopic surgery are
randomized to receive either phenylephrine low dose (0.5 mcg/kg/hr), phenylephrine high dose
(1.0 mcg/kg/min), or normal saline 5 minute before being placed in the beach chair position.
General anesthesia is induced with propofol, remifentanil and rocuronium (0.6 mg/kg) and the
trachea intubated. Anesthesia is maintained with sevoflurane and remifentanil targeting for
a BIS value 40-60. After hemodynamic stabilization, patients received on infusion of either
phenylephrine high dose (1.0 mcg/kg/min), phenylephrine low dose (0.5 mcg/kg/hr) or normal
saline 5 minute before being placed in the beach chair position. Following 15 minutes of
infusion study drugs, measurements of mean arterial blood pressure and cardiac function
(stroke volume variation, stroke volume index, and cardiac index) using Vigileo/Flotrac
system were made.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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