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NCT02379715 Clinical Trial

Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Anesthesia Clinical Trial

Official title:
Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02379715
Other study ID # AJIRB-MED-CT4-14-327
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date December 2014
Est. completion date May 2015

Study information
Verified date August 2020
Source Ajou University School of Medicine
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Desflurane is a halogenated ether with low solubility, giving rapid induction and emergence from anesthesia This character is suitable for Volatile Induction and Maintenance Anesthesia (VIMA). But desflurane can cause airway irritation when it used as a sole induction agent to adult or children, so there were many studies about reducing the airway reflex combined with desflurane.

Remifentanil is a short acting opioid and is quickly hydrolyzed by nonspecific esterase in the plasma and multiorgan. Several studies suggest the optimal dose of remifentanil for reducing airway reflex or cardiovascular response for intubation combined with desflurane. But these studies were under 1 Minimal Alveolar Concentration (MAC) of desflurane and this point could be a limitation because desflurane concentration over 1 MAC increase airway irritation significantly. This study this study was designed to determine a median effective effect-site concentration (EC50) of remifentanil to prevent airway irritation during desflurane anesthesia over 1 MAC.

Recruitment information / eligibility
Status Completed
Enrollment 26
Est. completion date May 2015
Est. primary completion date May 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 19 Years to 60 Years
Eligibility Inclusion Criteria:

- patients for surgery requiring general anesthesia

- American Society of Anesthesiologists(ASA) classification I, II

Exclusion Criteria:

- history of gastroesophageal reflux, High grade obesity, Predicted difficult airway, Asthma, Chronic obstructive pulmonary disease(COPD), Upper respiratory infection (URI) within 3 weeks

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Remifentanil

• Desflurane

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Ajou University School of Medicine

Outcome
Type Measure Description Time frame Safety issue
Primary Fail or success for induction with desflurane Failure for induction with desflurane is defined if there is a cough, laryngospasm, hypoxia or any refusal movement of patient. After loss of consciousness, 5 seconds
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