Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Anesthesia Clinical Trial

Official title:

Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02096224
• Other study ID #: CRBDSevoDes
• Status: Completed
• Phase: N/A
• First received: March 21, 2014
• Last updated: September 30, 2014
• Start date: May 2014
• Est. completion date: July 2014

Study information

• Verified date: March 2014
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Description:

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 108
• Est. completion date: July 2014
• Est. primary completion date: July 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients scheduled for transurethral bladder excision under general anesthesia

• ASA I-III

Exclusion Criteria:

• Bladder outflow obstruction

• Overactive bladder

• End-stage renal disease

• Neurogenic bladder

• Heart failure

• Arrhythmia

• Morbid obesity

• Use of chronic analgesic medication

• Hepatic disease

• Pulmonary disease

• Psychiatric disease

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Anesthesia
• Catheter Site Discomfort
• Complications
• Urinary Bladder Neoplasms

Intervention

Drug:
• Sevoflurane
Sevoflurane will be used.
• Desflurane
Desflurane will be used

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University of Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Catheter-related bladder discomfort	Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).	24 hour postoperatively	No
Secondary	Catheter-related bladder discomfort	Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).	0, 1, 6 and 24 hour postoperatively	No
Secondary	Nausea	The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.	0, 1, 6 and 24 hour postoperatively	No
Secondary	Vomiting	The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.	0, 1, 6 and 24 hour postoperatively	No
Secondary	Dry mouth	Dry mouth after the admission of operating room will be assessed. (score:0-10)	0 houe after admission of operating room	No