Effects on Immun System of Anesthesia

Anesthesia Clinical Trial

Official title:

Investigation Of The Effects Of General Anesthesia On The Oxidant/Antioxidant System

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02056561
• Other study ID #: MESUT-81
• Status: Completed
• Phase: N/A
• First received: January 29, 2014
• Last updated: February 5, 2014
• Start date: January 2010
• Est. completion date: January 2011

Study information

• Verified date: February 2014
• Source: Duzce University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Introduction and Aim: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes in oxidative stress and antioxidative defense mechanisms. The chemical structure of propofol is similar to some free radical consumers such as endogenous vitamin E and butylated hydroxene toluene. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy.

Material and Method: Forty-five patients, ASA (American Society of Anesthesiologists) I-II, score between 18-50 years with planned laparoscopic cholecystectomy under general anesthesia were included in the study. Patients were divided into 3 groups as total intravenous anesthesia (TIVA) (group T n: 15), sevoflurane (group S n: 15) and desflurane (group D n: 15). Propofol 2 mg/kg IV, fentanyl 1 mcg/kg IV, vecuronium 0.1 mg/kg IV given to all groups for anesthesia induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, 50% air and 50% O2 mix at 6 L/min flow. Group D were given 6% desflurane 50% air and 50% O2 mix at 6 L/min flow. Group T were given propofol infusions of 12 mg/kg/hr for the first 10 minutes, 9 mg/kg/hr for the second 10 minutes and 6 mg/kg/hr after that. Patients were ventilated with 50% air and 50% O2 mix at 6 L/min flow. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutathion peroxidase, total oxidants and antioxidants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: January 2011
• Est. primary completion date: July 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• ASA I-II with patients

• Between 18-50 years

• Planned laparoscopic cholecystectomy under general anesthetic

Exclusion Criteria:

• Patients with endocrine dysfunction

• blood transfusion in the previous 2 weeks

• signs of infection and inflammation

• history of preoperative medication use

• anemia

• hemorrhage requiring transfusion during the operation were excluded from the study.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Anesthesia

Locations

Country	Name	City	State
Turkey	Duzce Univercity Medical Fauculty	Duzce

Sponsors (1)

Lead Sponsor	Collaborator
Duzce University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Levels of glutathion peroxidase, total oxidants and antioxidants.	Before induction and after the operation venous blood samples were taken to evaluate the levels of glutathion peroxidase, total oxidants and antioxidants.	24 hours	Yes