Anesthesia Clinical Trial
Official title:
Investigation Of The Effects Of General Anesthesia On The Oxidant/Antioxidant System
Introduction and Aim: Desflurane and sevoflurane are frequently used for maintenance of
anesthesia and studies have shown that these anesthetics cause a variety of changes in
oxidative stress and antioxidative defense mechanisms. The chemical structure of propofol is
similar to some free radical consumers such as endogenous vitamin E and butylated hydroxene
toluene. This study aims to compare the effects of sevoflurane, desflurane and propofol
infusion anesthesia on the oxidant and antioxidant systems of patients undergoing
laparoscopic cholecystectomy.
Material and Method: Forty-five patients, ASA (American Society of Anesthesiologists) I-II,
score between 18-50 years with planned laparoscopic cholecystectomy under general anesthesia
were included in the study. Patients were divided into 3 groups as total intravenous
anesthesia (TIVA) (group T n: 15), sevoflurane (group S n: 15) and desflurane (group D n:
15). Propofol 2 mg/kg IV, fentanyl 1 mcg/kg IV, vecuronium 0.1 mg/kg IV given to all groups
for anesthesia induction. For maintenance of anesthesia group S were ventilated with 2%
sevoflurane, 50% air and 50% O2 mix at 6 L/min flow. Group D were given 6% desflurane 50%
air and 50% O2 mix at 6 L/min flow. Group T were given propofol infusions of 12 mg/kg/hr for
the first 10 minutes, 9 mg/kg/hr for the second 10 minutes and 6 mg/kg/hr after that.
Patients were ventilated with 50% air and 50% O2 mix at 6 L/min flow. Before induction and
after the operation venous blood samples were taken to evaluate the levels of glutathion
peroxidase, total oxidants and antioxidants.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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