Anesthetic Efficacy in Irreversible Pulpitis

Anesthesia Clinical Trial

Official title:

Anesthetic Efficacy of Articaine, Lidocaine and Mepivacaine in Patients With Irreversible Pulpitis of Mandibular Molar

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02054767
• Other study ID #: FDAAA
• Status: Completed
• Phase: Phase 4
• First received: September 3, 2013
• Last updated: January 31, 2014
• Start date: August 2010
• Est. completion date: July 2013

Study information

• Verified date: September 2013
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.

Description:

Conventional inferior alveolar nerve block (IANB) is the most commonly used technique for achieving pulpal anesthesia in posterior mandibular endodontic procedures. However, IANB has a high failure rate and success rates are even lower when applied for the treatment of mandibular posterior teeth with irreversible pulpitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 66
• Est. completion date: July 2013
• Est. primary completion date: November 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• clinical diagnosis of irreversible pulpitis

• good health

• had at least 1 adjacent tooth plus a healthy canine

Exclusion Criteria:

• took medication could be interacting with any of the anesthetics used

Study Design

Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Anesthesia
• Pulpitis

Intervention

Drug:
• Intervention: inferior alveolar nerve block injection
-22 patients received inferior alveolar nerve block injections of 3.6 mL (equivalent to 2 cartridges)

Locations

Country	Name	City	State
Brazil	Emergency Center of the School of Dentistry at the University of São Paulo	São Paulo

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	lip anesthesia	The investigators evaluated the subjective lip anethesia by asking the patient whether his/her lip was numb	ten minutes after the inferior alveolar nerve block	No
Primary	pulpal anesthesia	pulpal anesthesia was tested with an electric pulp stimulator	Ten minutes after the inferior alveolar nerve block	No
Secondary	analgesia	To evaluate the intensity of pain during the pulpectomy a verbal analogic scale was adopted	the patients were instructed to report any painful sensation at three phases: 1) dentin 2) pulp chamber 3) root canal	No