Target Effect-site Concentration of Remifentanil in Transperineal Prostate Puncture

Anesthesia, Intravenous Clinical Trial

Official title: The Research About the Target Effect-site Concentration of Remifentanil Inhibiting Stress Reaction of the Perineal Prostate Puncture When Dexmedetomidine Being Continuous Pumping

Status Recruiting

Clinical Trial Summary

The research about the target effect-site concentration of remifentanil, inhibiting stress reaction of the perineal prostate puncture when Dexmedetomidine being continuous pumping

Clinical Trial Description

Patients who were scheduled to undergo transperineal prostate puncture and biopsy were recruited into our study. In all patients, dexmedetomidine was injected at a bolus of 0.6 mg/kg and then continuously infused at 0.6 ug/kg/h using the conventional continuous microinfusion pump. the target Effect-site concentration of remifentanil was determined by sequential method. The first target effect-site concentration of remifentanil was set to 4.5ng/ml, the difference of adjacent target concentration was 0.5 ng/ml. Cardiovascular positive reaction was defined as the changes of heart rate or systolic blood pressure was more than 15% compared with baseline values, or body movement observed. The adjacent target concentration difference was adjusted to 0.2 ng/ml after 3 negative and positive reaction cycles. If the first had a cardiovascular positive reaction, the target concentration of remifentanil increased by a concentration gradient. Conversely, the target concentration of remifentanil decreased by a concentration gradient. ;

Related Conditions & MeSH terms

• Anesthesia, Intravenous

• NCT number: NCT03428191
• Study type: Observational [Patient Registry]
• Source: Chinese Medical Association
• Contact: Yi Zhou
• Phone: 13761293168
• Email: littlebaby89@163.com
• Status: Recruiting
• Phase: N/A
• Start date: January 2017
• Completion date: February 2018