Anesthesia, General Clinical Trial
Official title:
Computer-assisted Anaesthesia Using Pharmacokinetic/Pharmacodynamic Model
There are studies that suggest that unsatisfying levels of anesthesia can cause peri- and
postoperative complications in the patient undergoing surgery. Having a unnecessary "deep"
anesthesia level can be harmful, causing acute renal failure, injure to myocard, cause
delirium and increase the mortality rate. Being too "light", on the other hand, can make the
patient experience awareness when muscle relaxant is used. This can lead to serious
psychological struggles.
Evaluating the depth of anesthesia is the most important task of the anesthesia team, but can
be difficult because clinical signs depend on many factors. In addition to clinical
evaluation, EEG is commonly used for interpreting the level of anesthesia in todays practice.
Unfortunately, this method is not always accurate and has a delay.
New devices are now developed to calculate the anesthesia level based on the drugs given. The
level is simultaneously presented graphically on screen. The purpose of this study is to
investigate and compare clinical parameters within patients undergoing general anesthesia,
with and without the use of such devices. Hemodynamic stability, less use of adrenergics,
higher EEG-levels, a more rapid wake-up and shorter time in post operative care can indicate
a more precise level of anesthesia, hence, promote patient safety.
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