Anesthesia, General Clinical Trial
Official title:
General Anesthesia and Autonomic Nervous System in Children
The objective of the ANESPEDIA study is to describe in a pediatric population (aged from 4 to 8 years old) receiving elective surgery, the impact of general anesthesia on autonomic nervous system and their kinetics of early postoperative course (24 hours).
Some physiological factors such as sport activity or pathological as sepsis, certain chronic
diseases or diabetes are known to modulate the overall autonomic activity and the intrinsic
capacity of the individual to regulate its sympathovagal balance. These influences can alter
the physiological autonomic balance sometimes with positive consequences on the Cardiac
frequency-breathing control, blood pressure adjustment depending on the position of the
individual, on the status of blood volume, but sometimes deleterious with bad regulation of
sinus cardiac activity and respiration rate.
General anesthesia is recognized as one of the factors that can modify more or less
sustainable the sympathovagal autonomic balance. While many studies described the effects of
anesthesia on the autonomic nervous system, most data are done in adult subjects. For the
child who sees intrinsically autonomic physiological changes related to its maturative
status, assessment of the impact of anesthesia in the pediatric population in per and
postoperative was never realized.
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