The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Anesthesia, General Clinical Trial

Official title:

The Ratio of Hypnotic to Analgesic Potency of Sevoflurane and Desflurane : Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02698514
• Other study ID #: 2015-12-023
• Status: Completed
• Phase: Phase 3
• Start date: February 16, 2016
• Est. completion date: July 13, 2016

Study information

• Verified date: May 2018
• Source: Kangbuk Samsung Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.

Description:

Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: July 13, 2016
• Est. primary completion date: July 13, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing general anesthesia using volatile anesthetics and supraglottic airway (I-gel™)

• patients with american society of anesthesiologist physical status I, II

• patients aged 19-65 years

• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease

• patients who had received any medication affecting the central nervous system

• patients who had received medication affecting the sympathetic or parasympathetic nervous systems

• patients undergoing tracheal intubation for airway management

• pregnant women

Related Conditions & MeSH terms

• Anesthesia, General

Intervention

Drug:
• Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
• Desflurane
Anesthesia was maintained with desflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).

Locations

Country	Name	City	State
Korea, Republic of	Kangbuk Samsung Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Kangbuk Samsung Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Surgical pleth index	The analgesic potency of volatile anesthetics was evaluated by surgical pleth index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).	the 10 min at steady-state anesthesia after endotracheal intubation
Secondary	Bispectral index	The hypnotic potency of volatile anesthetics was evaluated by bispectral index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).	the 10 min at steady-state anesthesia after endotracheal intubation