Anesthesia; Functional Clinical Trial
Official title:
The Effect of Minimal Flow Sevoflurane Anesthesia on Blood Gas Analysis and Hemodynamic Parameters in Laparoscopic Cholecystectomies, a Randomised Controlled Trial.
NCT number | NCT04813952 |
Other study ID # | 1019 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | February 15, 2021 |
Est. completion date | May 10, 2021 |
Verified date | July 2021 |
Source | Sisli Hamidiye Etfal Training and Research Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations.
Status | Completed |
Enrollment | 70 |
Est. completion date | May 10, 2021 |
Est. primary completion date | April 30, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - ASA (American Society of Anesthesiologists) class I-II - The operation time between 60-180 minutes Exclusion Criteria: - Severe cardiac disease - COPD (Chronic Obstructive Pulmonary Disease) - Severe liver and kidney disease, - Diabetes mellitus - Morbid obesity - Alcohol and/or drug addiction - Risk or history of malignant hyperthermia - Pregnancy and lactation - Emergency cases - Operation time less than 60 minutes and longer than 180 minutes |
Country | Name | City | State |
---|---|---|---|
Turkey | Nebia Peker | Si?sli? | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Sisli Hamidiye Etfal Training and Research Hospital |
Turkey,
Doger C, Kahveci K, Ornek D, But A, Aksoy M, Gokcinar D, Katar D. Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery. Biomed Res Int. 2016;2016:3068467. doi: 10.1155/2016/3068467. Epub 2 — View Citation
Park SY, Chung CJ, Jang JH, Bae JY, Choi SR. The safety and efficacy of minimal-flow desflurane anesthesia during prolonged laparoscopic surgery. Korean J Anesthesiol. 2012 Dec;63(6):498-503. doi: 10.4097/kjae.2012.63.6.498. Epub 2012 Dec 14. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | CHANGE IN HR | Heart rate per minute | from the beginning to the end of anesthesia | |
Other | CHANGE IN MAP | Mean arterial pressure | from the beginning to the end of anesthesia | |
Primary | CHANGE IN P/F | PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction, not a percentage). P/F ratio is a widely used clinical indicator of hypoxaemia | from the beginning to the end of anesthesia | |
Primary | CHANGE IN PaCO2 | The partial pressure of carbon dioxide is the measure of carbon dioxide within arterial blood. | from the beginning to the end of anesthesia | |
Secondary | volatile agent consumption amount | the total amount of volatile agent (sevoflurane) consumed at the end of the surgery | from the beginning to the end of anesthesia |
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