Anesthesia Complication Clinical Trial
Official title:
Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial
Maintenance of a remifentanil infusion during anesthetic emergence has been reported to
decrease the incidence of coughing and thereby help to ensure a smooth emergence. It may,
however, cause respiratory depression and possibly delay emergence. The purpose of this study
was to investigate the effect of different dose of dexmedetomidine infusion on cough
suppression during emergence from general anesthesia in patients undergoing thyroid surgery.
American Society of Anesthesiologists physical status I-II adults undergoing elective
thyroidectomy under general anesthesia are recruited and randomly allocated to receive
dexmedetomidine iv infusion of 0.2μg·kg-1·h-1 (Group D1, n = 100), 0.5μg·kg-1·h-1 (Group D2,
n = 100), 0.7μg·kg-1·h-1 (Group D3, n = 100) or saline (Group C, n = 100). Primary outcome is
the incidence of coughing during emergence. Second outcomes include severity of coughing,
which is assessed using a four-point scale; Ramsay score, Bruggrmann comfort scale score, VAS
pain score are recorded. The respiratory rate (RR), heart rate (HR), and mean arterial
pressure are also recorded.
n/a
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