Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit

Status Recruiting

Clinical Trial Summary

Androgenetic alopecia is the most common type of alopecia in both men and women. About 80 % of Caucasian men and 40-50 % of Caucasian women are affected by androgenetic alopecia. The psychological impact of hair loss due to Androgenetic alopecia can be profound.

Clinical Trial Description

Currently, two medications are Food and Drug Administration approved in the treatment of Androgenetic alopecia which are minoxidil, and finasteride. Both medications must be taken indefinitely for benefits to persist. Hair transplantation is the only current successful permanent option. Nowadays, the majority of surgeons use 2 techniques, the classic strip technique, and the follicular unit extraction technique. Advantages of follicular unit extraction over the strip technique are the lesser incidence of donor zone post-procedural discomfort and the barely visible scarring.

Platelet rich plasma is an autologous concentration of platelets in small volume of plasma and is an exciting therapeutic option for hair growth. Combining platelet rich plasma with follicular unit extraction surgery for the treatment of Androgenetic alopecia demonstrated that PRP is able to minimize the postsurgical follicle loss and potentiate the performance of grafted hairs.

Adipose derived stem cells are an effective mesenchymal stem cell population with enormous potential in different fields of regenerative medicine.

Adipose stem cells are needed to induce the proliferation of bulge stem cells of hair follicle. Furthermore, they can help in wound healing and vascular neogenesis.

Zanzottera et al. 2014 investigated the effect of adipose derived stem cells on wound healing and engraftment of the transplanted hair applied during hair restoration surgery for three patients with androgenetic alopecia. Despite their promising results, further clinical trials including larger number of patients are still needed to confirm their preliminary findings. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03388840
Study type	Interventional
Source	Assiut University
Contact	Azza M Abdel-Meguid, PHD
Phone	01001801039
Email	azzamahfouz@yahoo.com
Status	Recruiting
Phase	Phase 4
Start date	January 15, 2018
Completion date	March 2021

View Details

See also
Status	Clinical Trial	Phase
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Completed	`NCT02729415` - Point-of-Care Adipose-derived Cells for Hair Growth	N/A
Completed	`NCT02279823` - A Phase 2 Study to Evaluate the Safety and Efficacy of CB-03-01 Solution, a Comparator Solution and Vehicle Solution in Males With Androgenetic Alopecia	Phase 2
Not yet recruiting	`NCT01227031` - Pharmacogenomic Study of Androgenetic Alopecia	N/A
Completed	`NCT00981461` - Treatment of Androgenetic Alopecia in Females, 9 Beam	N/A
Completed	`NCT01451021` - A Study to Evaluate and Compare Injections of Autologous Dermal and Epidermal Cells Into the Balding Scalp of Subjects With Hair Loss	Phase 2
Completed	`NCT00151515` - A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss	Phase 3
Completed	`NCT03694067` - Androgenetic Alopecia and the JAK-STAT Pathway
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms