Anaplastic Thyroid Cancer Clinical Trial
Official title:
Phase II Trial of BAY 43-9006 in Patients With Advanced Anaplastic Carcinoma of the Thyroid
This phase II trial is studying how well sorafenib works in treating patients with advanced anaplastic thyroid cancer. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
OBJECTIVES:
I. Determine whether the objective response rate is ≥ 20% in patients with advanced
anaplastic thyroid cancer treated with sorafenib.
II. Determine the survival of patients treated with this drug. III. Determine the safety
profile of this drug in these patients. IV. Determine the pharmacokinetic predictors of
response to this drug in these patients.
OUTLINE: This is a multicenter study.
Patients receive oral sorafenib twice daily on days 1-28. Courses repeat every 28 days in the
absence of disease progression or unacceptable toxicity. After completion of study treatment,
patients are followed for survival.
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