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NCT01739270 Clinical Trial

Dexamethasone Added to Levobupivacaine Improves Postoperative Analgesia

Analgesia Clinical Trial

Official title:
Dexamethasone Added to Levobupivacaine Improves Postoperative Analgesia After Supraclavicular Brachial Plexus Blockade

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT01739270
Other study ID # 0911
Secondary ID
Status Active, not recruiting
Phase N/A
First received November 25, 2012
Last updated July 28, 2015
Start date October 2012

Study information
Verified date July 2015
Source University Hospital Dubrava
Contact n/a
Is FDA regulated No
Health authority Croatia: Ministry of Science, Education and Sports
Study type Interventional

Clinical Trial Summary

Adding dexamethasone to local anesthetic will significantly prolong duration of brachial plexus anesthesia and analgesia.

Description:

Operations of upper extremities are often performed in regional anesthesia blocks. Single-injection blocks are effective, but time limited. Adding 4mg of dexamethasone to 0.5% levobupivacaine will significantly prolong duration of brachial plexus anesthesia and analgesia for fracture operations of upper extremity. This effect will result in less opioid use postoperatively.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 55
Est. completion date
Est. primary completion date January 2013
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- patients aged 18 years or older

- ASA (American Society of Anesthesiologists) physical status I, II or III

Exclusion Criteria:

- refusal of the patients to give informed consent

- preexisting coagulation disorders

- local infection at the site of the block

- neuropathy

- drug or alcohol abusers

- known allergy to the drug used in study

- operation time exceeding six hours

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Procedure:
• supraclavicular brachial plexus block

Locations
Country Name City State
Croatia Clinical Hospital Dubrava Zagreb

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Dubrava

Country where clinical trial is conducted

Croatia, 

References & Publications (3)

Kim YJ, Lee GY, Kim DY, Kim CH, Baik HJ, Heo S. Dexamathasone added to levobupivacaine improves postoperative analgesia in ultrasound guided interscalene brachial plexus blockade for arthroscopic shoulder surgery. Korean J Anesthesiol. 2012 Feb;62(2):130- — View Citation

Parrington SJ, O'Donnell D, Chan VW, Brown-Shreves D, Subramanyam R, Qu M, Brull R. Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):422-6. doi: 1 — View Citation

Vieira PA, Pulai I, Tsao GC, Manikantan P, Keller B, Connelly NR. Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade. Eur J Anaesthesiol. 2010 Mar;27(3):285-8. doi: 10.1097/EJA.0b013e3 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary duration of analgesia Duration of analgesia after supraclavicular block 24 hour postoperatively Yes
Secondary postoperative analgesic consumption 24 hour Yes
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