Anaesthesia Clinical Trial
— PANOOfficial title:
Impact of Perinatal Anaesthesia and Analgesia on Neurocognitive Outcomes in Early Childhood (PANO Study)
Verified date | March 2017 |
Source | KK Women's and Children's Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study aims to determine the impact of perinatal exposure to anaesthesia and analgesia on
neurocognitive outcomes in early childhood by analyzing neurocognitive data already obtained
from the local prospective observational cohort study: Growing up in Singapore Towards
Healthy Outcomes (GUSTO).
We hypothesize that:
1. Perinatal exposure to anaesthesia and analgesia is associated with poorer neurocognitive
outcomes at 6, 18, 24 and 36 months.
2. Maternal anxiety and depression during the antenatal and post-partum period is
associated with poorer neurocognitive outcomes at 6, 18 24 and 36 months.
Status | Active, not recruiting |
Enrollment | 468 |
Est. completion date | September 2020 |
Est. primary completion date | September 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Years to 4 Years |
Eligibility |
Inclusion Criteria: Infants who are enrolled in the neurocognitve arm of the GUSTO study (Growing up in Singapore Towards Healthy Outcomes). Exclusion Criteria: No information available on previous exposure (maternal exposure in utero, perinatal and postnatal exposure) to general anaesthesia, spinal or epidural anaesthesia. |
Country | Name | City | State |
---|---|---|---|
Singapore | KK Women's and Children's Hospital | Singapore |
Lead Sponsor | Collaborator |
---|---|
KK Women's and Children's Hospital | Singapore Institute for Clinical Sciences |
Singapore,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neurocognitive score | Composite Bayley-III Scores in the following domains tested at 24 months of age (cognitive, language, motor, socio-emotional, general adaptability) These scores are already available from the existing cohort and will be correlated with perinatal exposure to anaesthesia and analgesia and maternal anxiety and depression. | 24 months of age | |
Secondary | Neurocognitive Score (Deferred Imitation) | Neurocognitive scores as measured by deferred imitation, a test of memory and attention. These scores are already available from the existing cohort and will be correlated with perinatal exposure to anaesthesia and analgesia and maternal anxiety and depression. | 6, 18 and 24 months |
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